A uniquely effective skin rejuvenating formula developed by No7 the UK’s number one skincare brand1 in collaboration with University of Manchester dermatologists and skin scientists, is set to help millions of women around the world.

Following more than two decades of clinical trials in skin ageing, the team discovered the ‘therapeutic sweet spot’ for delivering retinol, a uniquely effective skin regenerator well recognised scientifically for boosting new surface skin increasing epidermal cell turnover and cell renewal. Retinol has been available since the 1960s, but is often difficult to deliver in a stable and effective form.

The ‘sweet spot’ centres on the discovery that less retinol is more. The breakthrough has led to No7, in collaboration with University of Manchester dermatologists and skin scientists, developing a clinically proven retinol formula, found in the new No7 Advanced Retinol 1.5% Complex Night Concentrate, which supports the natural elastic springs called fibrillin whilst increasing epidermal thickness and surface skin cell renewal.

Dr Mike Bell, No7 skincare scientific advisor, commented: “This is a next generation retinol product and is set to be a game changer for millions of women around the world to who want to transform the appearance of their skin, reducing visible fine lines, wrinkles, and pigmentation, as well as refining pores, and evening out skin tone and texture.”

Before this new research by the No7-Manchester team, and without compelling scientific proof, the beauty market has been driving towards retinol concentrations of 1.0% and above, believing them to drive better performance. However, these high concentrations have a greater potential to cause retinoid dermatitis, which can present as discomfort, redness and skin peeling. This in turn risks greater skin damage on exposure to the sun. In No7’s consumer trials run on a total over 300 women during their retinol development almost a third of women were unable to maintain compliance using a 1% retinol concentration with the majority of these having to stop using the product due to skin reactions. More than 90% showed good tolerance to a 0.3% retinol2 as found in the new No7 Advanced Retinol 1.5% Complex Night Concentrate.

Research on human volunteers has shown that the new formula containing just 0.3% retinol in an innovative encapsulated format and alongside soothing bisabolol (in a 1.5% complex), produces clinically proven skin improvements with minimal irritation3 while helping to reduce the appearance of wrinkles and restore radiant skin tone routinely lost with sun exposure and age.

Whilst there are other retinol formulations on the market, its inherent instability as an ingredient means it breaks down easily when exposed to air (or environment), For this reason, the No7 formulation is packaged under nitrogen conditions, with an airtight pump to protect retinol levels and product efficacy. The encapsulation technology is based around a natural polymer called inulin also protects the retinol from degradation.

The new retinol formula includes Matrixyl 3000+, an earlier advance in skin rejuvenation developed and proven by the same team. It is being launched this week (28 May 2020) as No7 Advanced Retinol 1.5% Complex Night Concentrate and will be a major step forward in the availability of truly effective and affordable age-defying skin treatments.

Details of the research4 which led to the development of the product will be presented at the Society of Investigative Dermatology (SID) meeting in America by skin specialist Rachel Watson, Professor of Cutaneous Science at The University of Manchester, who is renowned worldwide. It will then be published as a full study in a leading scientific journal.

“There is solid research evidence behind this new product,” said Professor Watson who pioneered accelerated repair skin patch testing in the study of photo-ageing, commonly viewed as the gold standard and long-used in No7 research5. This method was used in the development of the new No7 Advanced Retinol 1.5% Complex Night Concentrate and allowed the team to see improvements in epidermal thickness, cell renewal as well as in the natural fibrillin springs, “Improvement in surface cell turnover, general function and barrier function, is in my opinion a cosmetic breakthrough.”

No7 Advanced Retinol 1.5% Complex Night Concentrate, available at Boots.com RRP £34 for 30ml.


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